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KMID : 1023120110090010047
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Korean Journal of Aesthetic Society
2011 Volume.9 No. 1 p.47 ~ p.54
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Effect of MAL Extracts on Cholesterol Metabolism in High Cholesterol Fed Rabbits
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Park Jong-Bae
Lee Hye-Sook
Hwang Seok-Youn
Hong Seung-Bok
Kim Hee-Dong
Yun Chi-Young
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Abstract
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To investigate the effect of MAL(plant extracts) on cholesterol metabolism, male New Zealand White rabbits which were fed on high-cholesterol diet for 2 weeks were divided into the following 5 groups and fed on the experimental diet for 8 weeks : a normal diet group(ND, n=6), a high-cholesterol diet group(HCD, n=6), a high-cholesterol diet and lovastatin0.002%(HCD+lovastatin0.002%, n=6), a high-cholesterol diet and MAL 1% group(HCD+MAL1%, n=6), a high fat diet and MAL3% group(HCD+3%, n=6). The levels of blood total cholesterol, LDL-cholesterol and HDL-cholesterol were greatly increased by 2 weeks feeding on the high-cholesterol diet, compared with those of rabbits fed on normal diet. Blood concentrations of total cholesterol and LDL-cholesterol increased in HCD group after 8 weeks, whereas HDL-cholesterol significantly decreased. In the HCD+lovastatin0.002% group, the levels of blood total cholesterol, triglycerides and LDL-cholesterol were significantly reduced but there was no significant change in HDL-cholesterol. In the HCD+MAL1% group, the levels of blood triglyceride was decreased, but not in blood concentrations of total cholesterol. In the HCD+MAL3% group, the levels of blood total cholesterol and LDL-cholesterol reduced, in addition to less-severe decrease in HDL-cholesterol. The level of ALT and AST significantly increased in the HCD+lovastatin0.002% group, but not in groups fed MAL diets. These results suggest that MAL may improve lipid metabolism of serum and potentially reduce lipid storage.
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KEYWORD
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plant extracts, high-cholesterol diet, total cholesterol, triglyceride
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